2018

Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Murray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C; POLAR Trial Investigators and the ANZICS Clinical Trials Group. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. JAMA 2018 Dec 4;320(21):2211-2220


Salter R, Bailey M, Bellomo R, Eastwood G, Goodwin A, Nielsen N, Pilcher D, Nichol A, Saxena M, Shehabi Y, Young P; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE). Changes in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial. Crit Care Med. 2018 Nov;46(11):1722-1730


Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group. Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database. Crit Care. 2018 Oct 27;22(1):268


Gal M, Gobat N, Francis NA, Hood K, Butler CC, Bielicki J, Fraaij PL, Sharland M, Jarvis J, van Rossum AMC, Heikkinen T, Martinon-Torres F, Herberg J, Watkins A, Webb SAR, Moore R, Sukumar P, Nichol A. Priority Needs for Conducting Pandemic-Relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician-Researchers. Pediatr Infect Dis J. 2018 Sep 25


Young PJ, Bagshaw SM, Forbes A, Nichol A, Wright SE, Bellomo R, Bailey MJ, Beasley RW, Eastwood GM, Festa M, Gattas D, van Haren F, Litton E, Mouncey PR, Navarra L, Pilcher D, Mackle DM, McArthur CJ, McGuinness SP, Saxena MK, Webb S, Rowan KM; Australian and New Zealand Intensive Care Society Clinical Trials Group on behalf of the PEPTIC investigators. A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol. Crit Care Resusc. 2018 Sep;20(3):182-189.


Skrifvars MB, Moore E, Mårtensson J, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI Investigators and the ANZICS Clinical Trials Group. Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial. Acta Anaesthesiol Scand. 2019 Feb;63(2):200-207


Abe T, Madotto F, Pham T, Nagata I, Uchida M, Tamiya N, Kurahashi K, Bellani G, Laffey JG; LUNG-SAFE Investigators and the ESICM Trials Group. Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries. Crit Care. 2018 Aug 17;22(1):195


Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018 Sep;6(9):691-698


Cortegiani A, Madotto F, Gregoretti C, Bellani G, Laffey JG, Pham T, Van Haren F, Giarratano A, Antonelli M, Pesenti A, Grasselli G; LUNG SAFE Investigators and the ESICM Trials Group. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018 Jun 12;22(1):157


Hodgson C, Cooper DJ, Arabi Y, Bennett V, Bersten A, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Tuxen D, Vallance S, Young M, Nichol AD; PHARLAP Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure (PHARLAP): a protocol for a phase 2 trial in patients with acute respiratory distress syndrome. Crit Care Resusc. 2018 Jun;20(2):139-149


Nichol AD. The undiscovered country: therapeutic targeting of carbon dioxide levels in critically ill patients. Crit Care Resusc. 2018 Jun;20(2):81-82 


O'Leary RA, Nichol AD. Pathophysiology of severe traumatic brain injury.  J Neurosurg Sci. 2018 Oct;62(5):542-548


Presneill J, Gantner D, Nichol A, McArthur C, Forbes A, Kasza J, Trapani T, Murray L, Bernard S, Cameron P, Capellier G, Huet O, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Vallance S, Walker T, Webb S, James Cooper D; POLAR investigators and the ANZICS Clinical Trials Group.. Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial.  Trials. 2018 Apr 27;19(1):259


Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med. 2018 Apr 9


McQuilten ZK, French CJ, Nichol A, Higgins A, Cooper DJ. Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis. Transfus Med Rev. 2018 Apr;32(2):77-88


Webb SA, Nichol AD. Bending the Pandemic Curve: Improving Decision-Making With Clinical Research.  Crit Care Med. 2018 Mar;46(3):442-446


Gantner DC, Bailey M, Presneill J, French CJ, Nichol A, Little L, Bellomo R; EPO-TBI Investigators; and the ANZICS Clinical Trials Group. Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post-hoc Dose-effect Analysis. Ann Surg. 2018 Mar;267(3):585-589


Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.  Intensive Care Med. 2018 Jan;44(1):157-165


Gobat NH, Gal M, Butler CC, Webb SAR, Francis NA, Stanton H, Anthierens S, Bastiaens H, Godycki-Ćwirko M, Kowalczyk A, Pons-Vigués M, Pujol-Ribera E, Berenguera A, Watkins A, Sukumar P, Moore RG, Hood K, Nichol A. Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries. Health Expect. 2018 Feb;21(1):387-395

2017

Cosgrave D, Galligan M, Soukhin E, McMullan V, McGuinness S, Puttappa A, Conlon N, Boylan J, Hussain R, Doran P, Nichol A. The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial.  Trials. 2017 Dec 29;18(1):633


Skrifvars MB, French C, Bailey M, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R. Cause and timing of death and sub-group differential effects of erythropoietin in the EPO-TBI study. J Neurotrauma. 2017 Oct 12


Cooper DJ, McQuilten ZK, Nichol A, Ady B, Aubron C, Bailey M, Bellomo R, Gantner D, Irving DO, Kaukonen KM, McArthur C, Murray L, Pettilä V, French C; TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults. N Engl J Med. 2017 Nov 9;377(19):1858-1867


Eastwood GM, Nichol A, Wise MP. Targeted therapeutic mild hypercapnia after cardiac arrest. Crit Care. 2017 Jul 31;21(1):196


Parke RL, McGuinness S, Eastwood GM, Nichol A, Nielsen N, Dankiewicz J, Bellomo R. Co-enrolment for the TAME and TTM-2 trials: the cerebral option. Crit Care Resusc. 2017 Jun;19(2):99-100


Skrifvars MB, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group. Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial. J Trauma Acute Care Surg. 2017 Sep;83(3):449-456


Gobat NH, Butler CC, Webb SAR, Nichol A; PREPARE-EARL Study Team. Comment on Rishu et al. Time required to initiate outbreak and pandemic observational research. J Crit Care. 2017 Aug;40:271


Skrifvars MB, Bailey M, Presneill J, French C, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group. Venous thromboembolic events in critically ill traumatic brain injury patients. Intensive Care Med. 2017 Mar;43(3):419-428


Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, Esteban A, Gattinoni L, Bumbasirevic V, Piquilloud L, van Haren F, Larsson A, McAuley DF, Bauer PR, Arabi YM, Ranieri M, Antonelli M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study. Am J Respir Crit Care Med. 2017 Jan 1;195(1):67-77


French CJ, Glassford NJ, Gantner D, Higgins AM, Cooper DJ, Nichol A, Skrifvars MB, Imberger G, Presneill J, Bailey M, Bellomo R. Erythropoiesis-stimulating Agents in Critically Ill Trauma Patients: A Systematic Review and Meta-analysis.  Ann Surg. 2017 Jan;265(1):54-62

2011

Nichol A, Bailey M, Egi M, Pettila V, French C, Stachowski E, Reade MC, Cooper DJ, Bellomo R. Dynamic lactate indices as predictors of outcome in critically ill patients.  Crit Care. 2011;15(5):R242


Nichol AD. Permissive hypercapnia in acute respiratory distress syndrome - is now the time to get strict?  Crit Care Resusc. 2011 Sep;13(3):142-3


Hodgson CL, Tuxen DV, Davies AR, Bailey MJ, Higgins AM, Holland AE, Keating JL, Pilcher DV, Westbrook AJ, Cooper DJ, Nichol AD. A randomised controlled trial of an open lung strategy with staircase recruitment, titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome.  Crit Care. 2011;15(3):R133


Nichol AD, Trapani T, Murray L, Vallance S, Cooper DJ. Hypothermia in patients with brain injury: the way forward?  Lancet Neurol. 2011 May;10(5):405


Pettilä V, Westbrook AJ, Nichol AD, Bailey MJ, Wood EM, Syres G, Phillips LE, Street A, French C, Murray L, Orford N, Santamaria JD, Bellomo R, Cooper DJ; Blood Observational Study Investigators for ANZICS Clinical Trials Group. Age of red blood cells and mortality in the critically ill. Crit Care. 2011;15(2):R116


Moore EM, Nichol AD, Bernard SA, Bellomo R. Therapeutic hypothermia: benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury. Injury. 2011 Sep;42(9):843-54


Bellomo R, Bailey M, Eastwood GM, Nichol A, Pilcher D, Hart GK, Reade MC, Egi M, Cooper DJ; Study of Oxygen in Critical Care (SOCC) Group. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest.  Crit Care. 2011;15(2):R90


Nichol AD, Toal F, Fedi M, Cooper DJ. Early outcome prediction after severe traumatic brain injury: can multimodal magnetic resonance imaging assist in clinical prognostication for individual patients?  Crit Care Resusc. 2011 Mar;13(1):5-8


Egi M, Kim I, Nichol A, Stachowski E, French CJ, Hart GK, Hegarty C, Bailey M, Bellomo R. Ionized calcium concentration and outcome in critical illness.  Crit Care Med. 2011 Feb;39(2):314-21

2010

The incidence of acute kidney injury in patients with traumatic brain injury.

Moore EM, Bellomo R, Nichol A, Harley N, Macisaac C, Cooper DJ. Ren Fail. 2010;32(9):1060-5. doi: 10.3109/0886022X.2010.510234.

PMID:20863210

Article Link


Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury.

Nichol AD, O'Cronin DF, Naughton F, Hopkins N, Boylan J, McLoughlin P.

Anesthesiology. 2010 Jul;113(1):116-25. doi: 10.1097/ALN.0b013e3181dfd2fe.

PMID: 20526182

Article Link


Challenging issues in randomised controlled trials.

Nichol AD, Bailey M, Cooper DJ; POLAR; EPO Investigators.

Injury. 2010 Jul;41 Suppl 1:S20-3. doi: 10.1016/j.injury.2010.03.033. Epub 2010 Apr 22.

PMID:20413119

Article Link


Expensive care - a rationale for economic evaluations in intensive care.

Higgins AM, Pettila V, Bellomo R, Harris AH, Nichol AD, Morrison SS.

Crit Care Resusc. 2010 Mar;12(1):62-6. Review.

PMID:20196716

Article Link


Venous thromboembolism prophylaxis in the critically ill: a point prevalence survey of current practice in Australian and New Zealand intensive care units.

Robertson MS, Nichol AD, Higgins AM, Bailey MJ, Presneill JJ, Cooper DJ, Webb SA, McArthur C, MacIsaac CM; VTE Point Prevalence Investigators for the Australian and New Zealand Intensive Care Research Centre; Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2010 Mar;12(1):9-15.

PMID:20196708

Article Link


Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study.

Nichol AD, Egi M, Pettila V, Bellomo R, French C, Hart G, Davies A, Stachowski E, Reade MC, Bailey M, Cooper DJ. Crit Care. 2010;14(1):R25. doi: 10.1186/cc8888. Epub 2010 Feb 24.

PMID: 20181242

 

Hypercapnia and acidosis in sepsis: a double-edged sword?

Curley G, Contreras MM, Nichol AD, Higgins BD, Laffey JG.

Anesthesiology. 2010 Feb;112(2):462-72. doi: 10.1097/ALN.0b013e3181ca361f. Review.

PMID:20068449

Article Link


2009

Prospective observational study of postoperative complications after percutaneous dilatational or surgical tracheostomy in critically ill patients.

Barbetti JK, Nichol AD, Choate KR, Bailey MJ, Lee GA, Cooper DJ.

Crit Care Resusc. 2009 Dec;11(4):244-9.

PMID:20001871

Article Link


Red blood cell transfusion and mortality.

Pettilä V, Nichol AD, Bellomo R, Cooper DJ.

Crit Care Med. 2009 Nov;37(11):2996-7; author reply 2997. doi: 10.1097/CCM.0b013e3181b4a0a5. No abstract available.

PMID: 19851147

Article Link


Critical care services and 2009 H1N1 influenza in Australia and New Zealand.

ANZIC Influenza Investigators, Webb SA, Pettilä V, Seppelt I, Bellomo R, Bailey M, Cooper DJ, Cretikos M, Davies AR, Finfer S, Harrigan PW, Hart GK, Howe B, Iredell JR, McArthur C, Mitchell I, Morrison S, Nichol AD, Paterson DL, Peake S, Richards B, Stephens D, Turner A, Yung M.

N Engl J Med. 2009 Nov 12;361(20):1925-34. doi: 10.1056/NEJMoa0908481. Epub 2009 Oct 8.

PMID:19815860

Article Link


Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis.

Nichol AD, O'Cronin DF, Howell K, Naughton F, O'Brien S, Boylan J, O'Connor C, O'Toole D, Laffey JG, McLoughlin P. Crit Care Med. 2009 Nov;37(11):2953-61. doi: 10.1097/CCM.0b013e3181b028ce.

PMID: 19773647

Article Link


Can we improve neurological outcomes in severe traumatic brain injury? Something old (early prophylactic hypothermia) and something new (erythropoietin).

Nichol AD, Cooper DJ; POLAR Study Investigators on behalf of the ANZICS-Clinical Trials Group; EPO Study Investigators on behalf of the ANZICS-Clinical Trials Group. Injury. 2009 May;40(5):471-8. doi: 10.1016/j.injury.2009.01.002. Epub 2009 Apr 15. Review.

PMID: 19371869

Article Link